Endocrine Abstracts

Background: Obesity-linked metabolic disorders are a worldwide health concern affecting about one third of women of reproductive age. The programming events in utero impact the risk of predisposition to obesity and metabolic diseases. Maternal B12 deficiency is associated with higher cord lipids. B12 has a potential epigenetic role and therefore may perpetuate an intergenerational cycle of obesity through its effects on placental function and fetal metabolism. Therefore, we hy...

Background: Maternal B12 deficiency is linked with adverse metabolic disorders in infants. B12 has a potential epigenetic role which could influence placental dysfunction and fetal metabolism. Adipokines such as leptin and adiponectin play a major role in placental development by regulating lipid metabolism. Alterations in in-utero programming develop risk to obesity and metabolic diseases in offspring. B12 deficiency in mothers has been linked with higher cor...

Background: Vitamin B12 is crucial for placental development and fetal growth. B12 deficiency is associated with maternal obesity and adverse pregnancy outcomes. B12 is essential for the synthesis of S-Adenosyl methionine (SAM) which serves as a methyl donor in various cellular processes including DNA and RNA methylation. Pregnant women with low B12 have higher triglycerides, lower HDL and lower DNA methylation of cholesterol transcription factor. However, the...